It depends on what you intend to do, but for everyday versatility we suggest to run an .030” diameter solid ER70S-6 wire with a 90/10 (Argon/Carbon Dioxide) gas mix for welding in the shop and then have a variety of stick electrodes for welding outside or on stainless steel.
To weld aluminum, opt for a Spool Gun setup and run 100% Argon.